› 1xuc

X-ray diffraction
1.7Å resolution

Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor

Released:
DOI: 10.2210/pdb1xuc/pdb
PDB entry 1xuc coloured by chain, front view.
PDB entry 1xuc coloured by chain, side view.
PDB entry 1xuc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the highly selective inhibition of MMP-13.
Engel CK, Pirard B, Schimanski S, Kirsch R, Habermann J, Klingler O, Schlotte V, Weithmann KU, Wendt KU
Chem Biol 12 181-9 (2005)
PMID: 15734645

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 171 amino acids
Theoretical weight: 19.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45452 (Residues: 104-274; Coverage: 38%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand CA 4 x CA
Ligand PB3 2 x PB3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 134.437Å b: 36.476Å c: 95.32Å
α: 90° β: 130.507° γ: 90°
R-values:
R R work R free
0.175 0.175 0.2
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function.
Spinale FG. (2007)
32 more

11 mentions without citation

Peripheral membrane associations of matrix metalloproteinases.
Van Doren et al. (2017)
10 more