› 1xur

X-ray diffraction
1.85Å resolution

Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor

Released:
DOI: 10.2210/pdb1xur/pdb
PDB entry 1xur coloured by chain, front view.
PDB entry 1xur coloured by chain, side view.
PDB entry 1xur coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Making a new turn in matrix metalloprotease inhibition.
Wasserman ZR
Chem Biol 12 143-4 (2005)
PMID: 15734640

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-155288 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 171 amino acids
Theoretical weight: 19.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45452 (Residues: 104-274; Coverage: 38%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand CA 4 x CA
Ligand PB5 2 x PB5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 134.508Å b: 36.486Å c: 95.586Å
α: 90° β: 130.523° γ: 90°
R-values:
R R work R free
0.167 0.167 0.206
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Matrix metalloproteinase inhibitors (MMPIs) from marine natural products: the current situation and future prospects.
Zhang et al. (2009)
9 other articles

3 mentions without citation

Macrophage Migration Inhibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline.
Ko et al. (2019)
2 more