› 1y4e

Solution NMR

NMR structure of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger

Released:
DOI: 10.2210/pdb1y4e/pdb
PDB entry 1y4e coloured by chain, ensemble of 100 models, front view.
PDB entry 1y4e coloured by chain, ensemble of 100 models, side view.
PDB entry 1y4e coloured by chain, ensemble of 100 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger.
Slepkov ER, Rainey JK, Li X, Liu Y, Cheng FJ, Lindhout DA, Sykes BD, Fliegel L
J Biol Chem 280 17863-72 (2005)
PMID: 15677483

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/hydrogen exchanger 1 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 3.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19634 (Residues: 155-180; Coverage: 3%)
Gene names: APNH1, NHE1, SLC9A1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HSL 1 x HSL

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Structural and functional analysis of the Na+/H+ exchanger.
Slepkov et al. (2007)
9 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)