› 1yck

X-ray diffraction
1.7Å resolution

Crystal structure of human peptidoglycan recognition protein (PGRP-S)

Released:
DOI: 10.2210/pdb1yck/pdb
PDB entry 1yck coloured by chain, front view.
PDB entry 1yck coloured by chain, side view.
PDB entry 1yck coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.
Guan R, Wang Q, Sundberg EJ, Mariuzza RA
J Mol Biol 347 683-91 (2005)
PMID: 15769462

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131076 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidoglycan recognition protein 1 Chain: A
Molecule details ›
Chain: A
Length: 175 amino acids
Theoretical weight: 19.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75594 (Residues: 22-196; Coverage: 100%)
Gene names: PGLYRP, PGLYRP1, PGRP, SBBI68, TNFSF3L, UNQ639/PRO1269
Sequence domains: N-acetylmuramoyl-L-alanine amidase
Structure domains: Peptidoglycan recognition protein-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3221
Unit cell:
a: 72.12Å b: 72.12Å c: 51.79Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.183 0.21
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences.
Royet et al. (2007)
8 more

4 mentions without citation

The peptidoglycan recognition proteins (PGRPs).
Dziarski et al. (2006)
3 more