› 1yo8

X-ray diffraction
2.6Å resolution

Structure of the C-terminal domain of human thrombospondin-2

Released:
DOI: 10.2210/pdb1yo8/pdb
PDB entry 1yo8 coloured by chain, front view.
PDB entry 1yo8 coloured by chain, side view.
PDB entry 1yo8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the calcium-rich signature domain of human thrombospondin-2.
Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL
Nat Struct Mol Biol 12 910-4 (2005)
PMID: 16186819

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152920 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Thrombospondin-2 Chain: A
Molecule details ›
Chain: A
Length: 634 amino acids
Theoretical weight: 70.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35442 (Residues: 551-1172; Coverage: 54%)
Gene names: THBS2, TSP2
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand CA 30 x CA
1 modified residue:
Ligand MSE 5 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: I222
Unit cell:
a: 93.437Å b: 121.588Å c: 155.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.218 0.284
Expression system: Spodoptera frugiperda

Quick links

Citations

10 review citations

Thrombospondin-based antiangiogenic therapy.
Zhang et al. (2007)
9 more

12 mentions without citation

The thrombospondins.
Adams et al. (2011)
11 more