› 1yow

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162574 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Steroidogenic factor 1 Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13285 (Residues: 222-461; Coverage: 52%)
Gene names: AD4BP, FTZF1, NR5A1, SF1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
TIF2 peptide Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.04 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand P0E 1 x P0E
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P41212
Unit cell:
a: 73.335Å b: 73.335Å c: 139.021Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.246 0.29
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

78 review citations

Phosphoinositides: tiny lipids with giant impact on cell regulation.
Balla T. (2013)
77 more

7 mentions without citation

Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors.
Xie et al. (2009)
6 more