› 1yto

X-ray diffraction
2.1Å resolution

Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor

Released:
DOI: 10.2210/pdb1yto/pdb
PDB entry 1yto coloured by chain, front view.
PDB entry 1yto coloured by chain, side view.
PDB entry 1yto coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: effects upon structure, stability, folding, and mitogenic function.
Lee J, Dubey VK, Somasundaram T, Blaber M
Proteins 62 686-97 (2006)
PMID: 16355415

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 145 amino acids
Theoretical weight: 16.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 51.39Å b: 109.17Å c: 68.98Å
α: 90° β: 107.19° γ: 90°
R-values:
R R work R free
0.198 0.198 0.25
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Eukaryotic protein glycosylation: a primer for histochemists and cell biologists.
Corfield A. (2017)
3 other articles