› 1yuk

X-ray diffraction
1.8Å resolution

The crystal structure of the PSI/Hybrid domain/ I-EGF1 segment from the human integrin beta2 at 1.8 resolution

Released:
DOI: 10.2210/pdb1yuk/pdb
PDB entry 1yuk coloured by chain, front view.
PDB entry 1yuk coloured by chain, side view.
PDB entry 1yuk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution.
Shi M, Sundramurthy K, Liu B, Tan SM, Law SK, Lescar J
J Biol Chem 280 30586-93 (2005)
PMID: 15965234

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138493 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin beta-2 Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05107 (Residues: 23-125; Coverage: 14%)
Gene names: CD18, ITGB2, MFI7
Sequence domains: Integrin plexin domain
Structure domains:
Integrin beta-2 Chain: B
Molecule details ›
Chain: B
Length: 120 amino acids
Theoretical weight: 13.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05107 (Residues: 365-482; Coverage: 16%)
Gene names: CD18, ITGB2, MFI7
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NDG 2 x NDG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 58.6Å b: 31.818Å c: 74.95Å
α: 90° β: 91.2° γ: 90°
R-values:
R R work R free
0.234 0.234 0.253
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
9 more

6 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
5 more