› 1ywh

X-ray diffraction
2.7Å resolution

crystal structure of urokinase plasminogen activator receptor

Released:
DOI: 10.2210/pdb1ywh/pdb
PDB entry 1ywh coloured by chain, front view.
PDB entry 1ywh coloured by chain, side view.
PDB entry 1ywh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide.
Llinas P, Le Du MH, Gårdsvoll H, Danø K, Ploug M, Gilquin B, Stura EA, Ménez A
EMBO J 24 1655-63 (2005)
PMID: 15861141

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero hexadecamer
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162578 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Urokinase plasminogen activator surface receptor Chains: A, C, E, G, I, K, M, O
Molecule details ›
Chains: A, C, E, G, I, K, M, O
Length: 313 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q03405 (Residues: 23-335; Coverage: 100%)
Gene names: MO3, PLAUR, UPAR
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59
antagonist peptide Chains: B, D, F, H, J, L, N, P
Molecule details ›
Chains: B, D, F, H, J, L, N, P
Length: 13 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 11 x NAG
Ligand SO4 21 x SO4
3 modified residues:
Ligand ALC 8 x ALC
Ligand DSN 8 x DSN
Ligand DLY 8 x DLY

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 106.928Å b: 136.831Å c: 140.536Å
α: 90° β: 97.27° γ: 90°
R-values:
R R work R free
0.249 0.245 0.315
Expression systems:
  • Drosophila melanogaster
  • Not provided

Quick links

Citations

27 review citations

Regulation of cell signalling by uPAR.
Smith et al. (2010)
26 more

16 mentions without citation

Protein-protein docking benchmark version 4.0.
Hwang et al. (2010)
15 more