› 1yx4

Solution NMR

Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition

Released:
DOI: 10.2210/pdb1yx4/pdb
PDB entry 1yx4 coloured by chain, ensemble of 15 models, front view.
PDB entry 1yx4 coloured by chain, ensemble of 15 models, side view.
PDB entry 1yx4 coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition.
Wang Q, Young P, Walters KJ
J Mol Biol 348 727-39 (2005)
PMID: 15826667

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
26S proteasome non-ATPase regulatory subunit 4 Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 14.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55036 (Residues: 192-306; Coverage: 31%)
Gene names: MCB1, PSMD4
Sequence domains: Ubiquitin interaction motif
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Recognition and processing of ubiquitin-protein conjugates by the proteasome.
Finley D. (2009)
25 more

5 mentions without citation

Comparative proteomics reveals a significant bias toward alternative protein isoforms with conserved structure and function.
Ezkurdia et al. (2012)
4 more