› 1yxm

X-ray diffraction
1.9Å resolution

Crystal structure of peroxisomal trans 2-enoyl CoA reductase

Released:
DOI: 10.2210/pdb1yxm/pdb
PDB entry 1yxm coloured by chain, front view.
PDB entry 1yxm coloured by chain, side view.
PDB entry 1yxm coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jansson A, Ng S, Arrowsmith C, Sharma S, Edwards AM, Von Delft F, Sundstrom M, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189819 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisomal trans-2-enoyl-CoA reductase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 303 amino acids
Theoretical weight: 32.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9BY49 (Residues: 1-303; Coverage: 100%)
Gene names: PECR, PRO1004, SDR29C1
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

3 bound ligands:
Ligand SO4 4 x SO4
Ligand PO4 1 x PO4
Ligand ADE 1 x ADE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 78.152Å b: 119.014Å c: 119.909Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.245
Expression system: Escherichia coli BL21

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