› 1yzx

X-ray diffraction
1.93Å resolution

Crystal structure of human kappa class glutathione transferase

Released:
DOI: 10.2210/pdb1yzx/pdb
PDB entry 1yzx coloured by chain, front view.
PDB entry 1yzx coloured by chain, side view.
PDB entry 1yzx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme.
Li J, Xia Z, Ding J
Protein Sci 14 2361-9 (2005)
PMID: 16081649

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase kappa 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 226 amino acids
Theoretical weight: 25.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y2Q3 (Residues: 1-226; Coverage: 100%)
Gene names: GSTK1, HDCMD47P
Sequence domains: DSBA-like thioredoxin domain
Structure domains: Glutaredoxin

Ligands and Environments


Cofactor: Ligand GSF 2 x GSF
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: C2
Unit cell:
a: 98.275Å b: 118.274Å c: 52.591Å
α: 90° β: 102.67° γ: 90°
R-values:
R R work R free
0.182 0.18 0.204
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Glutathione transferases in the genomics era: new insights and perspectives.
Frova C. (2006)
7 more

4 mentions without citation

Predicting new indications for approved drugs using a proteochemometric method.
Dakshanamurthy et al. (2012)
3 more