› 1z11

X-ray diffraction
2.05Å resolution

Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound

Released:
DOI: 10.2210/pdb1z11/pdb
PDB entry 1z11 coloured by chain, front view.
PDB entry 1z11 coloured by chain, side view.
PDB entry 1z11 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen.
Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF
Nat Struct Mol Biol 12 822-3 (2005)
PMID: 16086027

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2A6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 476 amino acids
Theoretical weight: 54.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11509 (Residues: 25-494; Coverage: 95%)
Gene names: CYP2A3, CYP2A6
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

2 bound ligands:
Ligand HEM 4 x HEM
Ligand 8MO 4 x 8MO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 70.66Å b: 159.03Å c: 103.88Å
α: 90° β: 92° γ: 90°
R-values:
R R work R free
0.221 0.219 0.261
Expression system: Escherichia coli

Quick links

Citations

37 review citations

Polymorphism of human cytochrome P450 enzymes and its clinical impact.
Zhou et al. (2009)
36 more

21 mentions without citation

Cooperative properties of cytochromes P450.
Denisov et al. (2009)
20 more