› 1z23

Solution NMR

The serine-rich domain from Crk-associated substrate (p130Cas)

Released:
DOI: 10.2210/pdb1z23/pdb
PDB entry 1z23 coloured by chain, ensemble of 20 models, front view.
PDB entry 1z23 coloured by chain, ensemble of 20 models, side view.
PDB entry 1z23 coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle.
Briknarová K, Nasertorabi F, Havert ML, Eggleston E, Hoyt DW, Li C, Olson AJ, Vuori K, Ely KR
J Biol Chem 280 21908-14 (2005)
PMID: 15795225

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179035 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Breast cancer anti-estrogen resistance protein 1 Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 17.35 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q63767 (Residues: 546-708; Coverage: 17%)
Gene names: Bcar1, Cas, Crkas
Sequence domains: Serine rich protein interaction domain
Structure domains: Serine-rich domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

14-3-3 proteins as potential oncogenes.
Tzivion et al. (2006)
4 more

3 mentions without citation

CAS proteins in normal and pathological cell growth control.
Tikhmyanova et al. (2010)
2 more