› 1z3s

X-ray diffraction
2.35Å resolution

Angiopoietin-2 Receptor Binding Domain

Released:
DOI: 10.2210/pdb1z3s/pdb
PDB entry 1z3s coloured by chain, front view.
PDB entry 1z3s coloured by chain, side view.
PDB entry 1z3s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.
Barton WA, Tzvetkova D, Nikolov DB
Structure 13 825-32 (2005)
PMID: 15893672

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiopoietin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 217 amino acids
Theoretical weight: 24.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15123 (Residues: 281-496; Coverage: 45%)
Gene name: ANGPT2
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: C2
Unit cell:
a: 74.19Å b: 136.448Å c: 47.732Å
α: 90° β: 93.43° γ: 90°
R-values:
R R work R free
0.229 0.229 0.287
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The role of monocytes in angiogenesis and atherosclerosis.
Jaipersad et al. (2014)
10 more

4 mentions without citation

Structural basis for angiopoietin-1-mediated signaling initiation.
Yu et al. (2013)
3 more