› 1z60

Solution NMR

Solution structure of the carboxy-terminal domain of human TFIIH P44 subunit

Released:
DOI: 10.2210/pdb1z60/pdb
PDB entry 1z60 coloured by chain, ensemble of 10 models, front view.
PDB entry 1z60 coloured by chain, ensemble of 10 models, side view.
PDB entry 1z60 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions.
Kellenberger E, Dominguez C, Fribourg S, Wasielewski E, Moras D, Poterszman A, Boelens R, Kieffer B
J Biol Chem 280 20785-92 (2005)
PMID: 15790571

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171831 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
General transcription factor IIH subunit 2 Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13888 (Residues: 328-386; Coverage: 15%)
Gene names: BTF2P44, GTF2H2
Sequence domains: TFIIH C1-like domain
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

The general transcription machinery and general cofactors.
Thomas et al. (2006)
5 more

6 mentions without citation

Structures of transcription pre-initiation complex with TFIIH and Mediator.
Schilbach et al. (2017)
5 more