› 1z6w

Solution NMR

Human Lactoferricin

Released:
DOI: 10.2210/pdb1z6w/pdb
PDB entry 1z6w coloured by chain, ensemble of 20 models, front view.
PDB entry 1z6w coloured by chain, ensemble of 20 models, side view.
PDB entry 1z6w coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent.
Hunter HN, Demcoe AR, Jenssen H, Gutteberg TJ, Vogel HJ
Antimicrob Agents Chemother 49 3387-95 (2005)
PMID: 16048952

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactoferricin-H Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02788 (Residues: 21-67; Coverage: 7%)
Gene names: GIG12, LF, LTF

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

23 review citations

Peptide antimicrobial agents.
Jenssen et al. (2006)
22 more

3 mentions without citation

Time to Kill and Time to Heal: The Multifaceted Role of Lactoferrin and Lactoferricin in Host Defense.
Ohradanova-Repic et al. (2023)
2 more