› 1z7j

X-ray diffraction
2.2Å resolution

Human transthyretin (also called prealbumin) complex with 3, 3',5,5'-tetraiodothyroacetic acid (t4ac)

Released:
DOI: 10.2210/pdb1z7j/pdb
PDB entry 1z7j coloured by chain, front view.
PDB entry 1z7j coloured by chain, side view.
PDB entry 1z7j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution.
Neumann P, Cody V, Wojtczak A
Acta Crystallogr D Biol Crystallogr 61 1313-9 (2005)
PMID: 16204882

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand T4A 2 x T4A
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 43.462Å b: 85.858Å c: 65.443Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.173 0.217

Quick links

Citations

3 review citations

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.
Connelly et al. (2010)
2 more

1 mention without citation

Rigorous treatment of multispecies multimode ligand-receptor interactions in 3D-QSAR: CoMFA analysis of thyroxine analogs binding to transthyretin.
Natesan et al. (2011)