› 1z7z

Electron Microscopy
8Å resolution

Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi

Released:
DOI: 10.2210/pdb1z7z/pdb
PDB entry 1z7z coloured by chain, front view.
PDB entry 1z7z coloured by chain, side view.
PDB entry 1z7z coloured by chain, top view.
Source organisms:
Primary publication:
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.
Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG
Structure 13 1019-33 (2005)
PMID: 16004874
Related structures: EMD-1114

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero 360-mer (preferred)
PDBe Complex ID:
PDB-CPX-138636 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
human coxsackievirus A21 Chain: 1
Molecule details ›
Chain: 1
Length: 286 amino acids
Theoretical weight: 31.95 KDa
Source organism: Coxsackievirus A21
UniProt:
  • Canonical: Q7T7N6 (Residues: 582-867; Coverage: 13%)
Sequence domains: picornavirus capsid protein
human coxsackievirus A21 Chain: 2
Molecule details ›
Chain: 2
Length: 272 amino acids
Theoretical weight: 29.92 KDa
Source organism: Coxsackievirus A21
UniProt:
  • Canonical: Q7T7N6 (Residues: 70-341; Coverage: 12%)
Sequence domains: picornavirus capsid protein
human coxsackievirus A21 Chain: 3
Molecule details ›
Chain: 3
Length: 234 amino acids
Theoretical weight: 25.9 KDa
Source organism: Coxsackievirus A21
UniProt:
  • Canonical: Q7T7N6 (Residues: 342-575; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP1 Chain: 4
Molecule details ›
Chain: 4
Length: 12 amino acids
Theoretical weight: 1.34 KDa
Source organism: Coxsackievirus A21
UniProt:
  • Canonical: P22055 (Residues: 869-879; Coverage: 1%)
human coxsackievirus A21 Chain: 5
Molecule details ›
Chain: 5
Length: 6 amino acids
Theoretical weight: 688 Da
Source organism: Coxsackievirus A21
Intercellular adhesion molecule 1 Chain: I
Molecule details ›
Chain: I
Length: 450 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05362 (Residues: 28-477; Coverage: 89%)
Gene name: ICAM1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8Å
Relevant EMDB volumes: EMD-1114

Quick links

Citations

10 review citations

Immunoglobulin superfamily cell adhesion molecules: zippers and signals.
Aricescu et al. (2007)
9 more

14 mentions without citation

Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview.
Lermyte F. (2020)
13 more