Function and Biology Details
Reaction catalysed:
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin domain
- SRCR-like domain superfamily
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
- Peptidase S1, PA clan
- Peptidase S1, PA clan, chymotrypsin-like fold
- SRCR-like domain
1 more domain
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138847 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine protease hepsin catalytic chain
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 40.45 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
Sequence domains:
Structure domains:
Length: 372 amino acids
Theoretical weight: 40.45 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
- Canonical:
P05981 (Residues: 46-417; Coverage: 89%)
Sequence domains:
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU RUH3R
Spacegroup:
P21
Expression systems:
- Komagataella pastoris
- Not provided
