› 1z9e

Solution NMR

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

Released:
DOI: 10.2210/pdb1z9e/pdb
PDB entry 1z9e coloured by chain, ensemble of 15 models, front view.
PDB entry 1z9e coloured by chain, ensemble of 15 models, side view.
PDB entry 1z9e coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.
Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman A
Nat Struct Mol Biol 12 526-32 (2005)
PMID: 15895093

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PC4 and SFRS1-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O75475 (Residues: 346-471; Coverage: 24%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Structure domains: Conserved domain common to transcription factors TFIIS, elongin A, CRSP70

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

36 review citations

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.
Engelman et al. (2008)
35 more

9 mentions without citation

Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.
Engelman AN. (2019)
8 more