› 1zcn

X-ray diffraction
1.9Å resolution

human Pin1 Ng mutant

Released:
DOI: 10.2210/pdb1zcn/pdb
PDB entry 1zcn coloured by chain, front view.
PDB entry 1zcn coloured by chain, side view.
PDB entry 1zcn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function-folding relationship in a WW domain.
Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel JP, Gruebele M, Kelly JW
Proc Natl Acad Sci U S A 103 10648-53 (2006)
PMID: 16807295

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171737 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13526 (Residues: 1-163; Coverage: 99%)
Gene name: PIN1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PO4 1 x PO4
Ligand 1PE 2 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P43212
Unit cell:
a: 49.108Å b: 49.108Å c: 135.095Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.269
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

17 review citations

Transition networks for modeling the kinetics of conformational change in macromolecules.
Noé et al. (2008)
16 more

9 mentions without citation

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.
Thapar R. (2015)
8 more