› 1ziw

X-ray diffraction
2.1Å resolution

Human Toll-like Receptor 3 extracellular domain structure

Released:
DOI: 10.2210/pdb1ziw/pdb
PDB entry 1ziw coloured by chain, front view.
PDB entry 1ziw coloured by chain, side view.
PDB entry 1ziw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.
Choe J, Kelker MS, Wilson IA
Science 309 581-5 (2005)
PMID: 15961631

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127471 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Toll-like receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 680 amino acids
Theoretical weight: 77.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15455 (Residues: 27-700; Coverage: 77%)
Gene name: TLR3
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand SO4 2 x SO4
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2221
Unit cell:
a: 138.497Å b: 155.121Å c: 119.669Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.248
Expression system: Spodoptera frugiperda

Quick links

Citations

169 review citations

Pathogen recognition and innate immunity.
Akira et al. (2006)
168 more

70 mentions without citation

TLRs and innate immunity.
Beutler BA. (2009)
69 more