› 1zkz

X-ray diffraction
2.33Å resolution

Crystal Structure of BMP9

Released:
DOI: 10.2210/pdb1zkz/pdb
PDB entry 1zkz coloured by chain, front view.
PDB entry 1zkz coloured by chain, side view.
PDB entry 1zkz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of BMP-9 and functional interactions with pro-region and receptors.
Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S
J Biol Chem 280 25111-8 (2005)
PMID: 15851468

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth/differentiation factor 2 Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9UK05 (Residues: 320-429; Coverage: 27%)
Gene names: BMP9, GDF2
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: I4122
Unit cell:
a: 71.234Å b: 71.234Å c: 144.897Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.272
Expression system: Cricetulus griseus

Quick links

Citations

60 review citations

Bone morphogenetic protein receptors and signal transduction.
Miyazono et al. (2010)
59 more

6 mentions without citation

Structural basis for the inhibition of activin signalling by follistatin.
Harrington et al. (2006)
5 more