› 1zlt

X-ray diffraction
1.74Å resolution

Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog

Released:
DOI: 10.2210/pdb1zlt/pdb
PDB entry 1zlt coloured by chain, front view.
PDB entry 1zlt coloured by chain, side view.
PDB entry 1zlt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lee CC, Ng K, Wan Y, Gray N, Spraggon G

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 33.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14757 (Residues: 1-289; Coverage: 61%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand HYM 1 x HYM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P21
Unit cell:
a: 45Å b: 65.643Å c: 58.112Å
α: 90° β: 94.71° γ: 90°
R-values:
R R work R free
0.227 0.227 0.265
Expression system: Spodoptera frugiperda

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