› 1zmh

X-ray diffraction
1.5Å resolution

Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala)

Released:
DOI: 10.2210/pdb1zmh/pdb
PDB entry 1zmh coloured by chain, front view.
PDB entry 1zmh coloured by chain, side view.
PDB entry 1zmh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
Xie C, Prahl A, Ericksen B, Wu Z, Zeng P, Li X, Lu WY, Lubkowski J, Lu W
J Biol Chem 280 32921-9 (2005)
PMID: 15894545

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-157841 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil defensin 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 29 amino acids
Theoretical weight: 3.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P59666 (Residues: 66-94; Coverage: 39%)
Gene names: DEF3, DEFA3
Sequence domains: Mammalian defensin

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand P6G 1 x P6G
Ligand GOL 2 x GOL
1 modified residue:
Ligand DAL 4 x DAL

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P2
Unit cell:
a: 42.038Å b: 26.051Å c: 61.587Å
α: 90° β: 105.79° γ: 90°
R-values:
R R work R free
0.179 0.177 0.213
Expression system: Escherichia coli

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Citations

7 review citations

The roles of antimicrobial peptides in innate host defense.
Diamond et al. (2009)
6 more