› 1zmq

X-ray diffraction
2.1Å resolution

Crystal structure of human alpha-defensin-6

Released:
DOI: 10.2210/pdb1zmq/pdb
PDB entry 1zmq coloured by chain, front view.
PDB entry 1zmq coloured by chain, side view.
PDB entry 1zmq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J
Protein Sci 15 2749-60 (2006)
PMID: 17088326

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Defensin-6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 32 amino acids
Theoretical weight: 3.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01524 (Residues: 69-100; Coverage: 40%)
Gene names: DEF6, DEFA6
Sequence domains: Mammalian defensin

Ligands and Environments

1 bound ligand:
Ligand CL 8 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P41212
Unit cell:
a: 62.068Å b: 62.068Å c: 145.297Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.193
Expression system: Escherichia coli

Quick links

Citations

34 review citations

The roles of antimicrobial peptides in innate host defense.
Diamond et al. (2009)
33 more

19 mentions without citation

The antimicrobial peptides and their potential clinical applications.
Lei et al. (2019)
18 more