› 1znc

X-ray diffraction
2.8Å resolution

HUMAN CARBONIC ANHYDRASE IV

Released:
DOI: 10.2210/pdb1znc/pdb
PDB entry 1znc coloured by chain, front view.
PDB entry 1znc coloured by chain, side view.
PDB entry 1znc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.
Stams T, Nair SK, Okuyama T, Waheed A, Sly WS, Christianson DW
Proc Natl Acad Sci U S A 93 13589-94 (1996)
PMID: 8942978

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 30.36 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P22748 (Residues: 19-284; Coverage: 91%)
Gene name: CA4
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: C2
Unit cell:
a: 89.5Å b: 47.7Å c: 141Å
α: 90° β: 106.3° γ: 90°
R-values:
R R work R free
0.197 0.197 0.252
Expression system: Cricetulus griseus

Quick links

Citations

18 review citations

Carbonic anhydrase inhibitors.
Supuran et al. (2003)
17 more

22 mentions without citation

Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding.
Krishnamurthy et al. (2008)
21 more