› 1znq

X-ray diffraction
2.5Å resolution

Crystal Structure of Human Liver GAPDH

Released:
DOI: 10.2210/pdb1znq/pdb
PDB entry 1znq coloured by chain, front view.
PDB entry 1znq coloured by chain, side view.
PDB entry 1znq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ismail SA, Park HW

Function and Biology Details

Reaction catalysed: 
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137626 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glyceraldehyde-3-phosphate dehydrogenase Chains: O, P, Q, R
Molecule details ›
Chains: O, P, Q, R
Length: 338 amino acids
Theoretical weight: 36.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04406 (Residues: 1-335; Coverage: 100%)
Gene names: CDABP0047, GAPD, GAPDH, OK/SW-cl.12
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 4 x NAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 124.5Å b: 132.31Å c: 86.037Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.229
Expression system: Escherichia coli BL21(DE3)

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