› 1zq9

X-ray diffraction
1.9Å resolution

Crystal structure of human Dimethyladenosine transferase

Released:
DOI: 10.2210/pdb1zq9/pdb
PDB entry 1zq9 coloured by chain, front view.
PDB entry 1zq9 coloured by chain, side view.
PDB entry 1zq9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Wu H, Zeng H, Loppnau P, Sundstrom M, Arrowsmith C, Edwards A, Bochkarev A, Plotnikov A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable dimethyladenosine transferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 285 amino acids
Theoretical weight: 32.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UNQ2 (Residues: 31-313; Coverage: 90%)
Gene names: DIMT1, DIMT1L, HUSSY-05
Sequence domains: Ribosomal RNA adenine dimethylase
Structure domains:

Ligands and Environments


Cofactor: Ligand SAM 2 x SAM
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P21
Unit cell:
a: 39.629Å b: 185.243Å c: 45.072Å
α: 90° β: 91.3° γ: 90°
R-values:
R R work R free
0.165 0.164 0.235
Expression system: Escherichia coli BL21(DE3)

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