› 1zs5

Solution NMR

Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association

Released:
DOI: 10.2210/pdb1zs5/pdb
PDB entry 1zs5 coloured by chain, front view.
PDB entry 1zs5 coloured by chain, side view.
PDB entry 1zs5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zeng L, Godbole S, Muller M, Yan S, Sanchez R, Zhou M

Function and Biology Details

Reactions catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187769 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT2B Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 14.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92831 (Residues: 719-832; Coverage: 14%)
Gene names: KAT2B, PCAF
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand MIB 1 x MIB
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression system: Escherichia coli BL21(DE3)

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