› 1zsd

X-ray diffraction
1.7Å resolution

Crystal Structure Of HLA-B*3501 Presenting an 11-Mer EBV Antigen EPLPQGQLTAY

Released:
DOI: 10.2210/pdb1zsd/pdb
PDB entry 1zsd coloured by chain, front view.
PDB entry 1zsd coloured by chain, side view.
PDB entry 1zsd coloured by chain, top view.
Source organisms:
Primary publication:
CTL recognition of a bulged viral peptide involves biased TCR selection.
Miles JJ, Elhassen D, Borg NA, Silins SL, Tynan FE, Burrows JM, Purcell AW, Kjer-Nielsen L, Rossjohn J, Burrows SR, McCluskey J
J Immunol 175 3826-34 (2005)
PMID: 16148129

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135131 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Lytic switch protein BZLF1 Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Human herpesvirus 4 strain B95-8
Expression system: Not provided
UniProt:
  • Canonical: P03206 (Residues: 54-64; Coverage: 5%)
Gene name: BZLF1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 50.93Å b: 81.49Å c: 109.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.246
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

16 review citations

Cellular responses to viral infection in humans: lessons from Epstein-Barr virus.
Hislop et al. (2007)
15 more

10 mentions without citation

Prioritization of potential vaccine targets using comparative proteomics and designing of the chimeric multi-epitope vaccine against Pseudomonas aeruginosa.
Solanki et al. (2019)
9 more