› 1zsy

X-ray diffraction
1.75Å resolution

The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)

Released:
DOI: 10.2210/pdb1zsy/pdb
PDB entry 1zsy coloured by chain, front view.
PDB entry 1zsy coloured by chain, side view.
PDB entry 1zsy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lukacik P, Shafqat N, Kavanagh KL, Johansson C, Smee C, Edwards A, Arrowsmith C, Sundstrom M, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189754 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 38.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BV79 (Residues: 40-373; Coverage: 90%)
Gene names: CGI-63, MECR, NBRF1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I222
Unit cell:
a: 74.19Å b: 117.184Å c: 127.372Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.17 0.195
Expression system: Escherichia coli BL21(DE3)

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