› 1zt5

X-ray diffraction
1.82Å resolution

C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)

Released:
DOI: 10.2210/pdb1zt5/pdb
PDB entry 1zt5 coloured by chain, front view.
PDB entry 1zt5 coloured by chain, side view.
PDB entry 1zt5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid.
Sala A, Capaldi S, Campagnoli M, Faggion B, Labò S, Perduca M, Romano A, Carrizo ME, Valli M, Visai L, Minchiotti L, Galliano M, Monaco HL
J Biol Chem 280 29812-9 (2005)
PMID: 15972819

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140389 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 9.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08833 (Residues: 172-251; Coverage: 34%)
Gene names: IBP1, IGFBP1
Sequence domains: Thyroglobulin type-1 repeat
Structure domains: Thyroglobulin type-1

Ligands and Environments

2 bound ligands:
Ligand FE2 1 x FE2
Ligand DIO 1 x DIO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21212
Unit cell:
a: 38.21Å b: 59.6Å c: 31.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.222 0.264

Quick links

Citations

5 review citations

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis.
Wheatcroft et al. (2009)
4 more

6 mentions without citation

Defining the pathway to insulin-like growth factor system targeting in cancer.
Rosenzweig et al. (2010)
5 more