› 1zuc

X-ray diffraction
2Å resolution

Progesterone receptor ligand binding domain in complex with the nonsteroidal agonist tanaproget

Released:
DOI: 10.2210/pdb1zuc/pdb
PDB entry 1zuc coloured by chain, front view.
PDB entry 1zuc coloured by chain, side view.
PDB entry 1zuc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget.
Zhang Z, Olland AM, Zhu Y, Cohen J, Berrodin T, Chippari S, Appavu C, Li S, Wilhem J, Chopra R, Fensome A, Zhang P, Wrobel J, Unwalla RJ, Lyttle CR, Winneker RC
J Biol Chem 280 28468-75 (2005)
PMID: 15937332

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139041 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Progesterone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P06401 (Residues: 676-933; Coverage: 28%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand T98 2 x T98
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 57.519Å b: 64.497Å c: 70.406Å
α: 90° β: 95.76° γ: 90°
R-values:
R R work R free
0.181 0.179 0.228
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

Nuclear receptor structure: implications for function.
Bain et al. (2007)
7 more

9 mentions without citation

Structural protein-ligand interaction fingerprints (SPLIF) for structure-based virtual screening: method and benchmark study.
Da et al. (2014)
8 more