› 1zw9

X-ray diffraction
1.9Å resolution

Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine

Released:
DOI: 10.2210/pdb1zw9/pdb
PDB entry 1zw9 coloured by chain, front view.
PDB entry 1zw9 coloured by chain, side view.
PDB entry 1zw9 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Entry authors: Immormino RM, Gewirth DT, Chiosis G

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136252 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent molecular chaperone HSP82 Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 27.04 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P02829 (Residues: 1-220; Coverage: 31%)
Gene names: HSP82, HSP90, YPL240C
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand H64 1 x H64
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P4322
Unit cell:
a: 73.76Å b: 73.76Å c: 110.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.223
Expression system: Escherichia coli

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