› 1zys

X-ray diffraction
1.7Å resolution

Co-crystal structure of Checkpoint Kinase Chk1 with a pyrrolo-pyridine inhibitor

Released:
DOI: 10.2210/pdb1zys/pdb
PDB entry 1zys coloured by chain, front view.
PDB entry 1zys coloured by chain, side view.
PDB entry 1zys coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Stavenger RA, Zhao B, Zhou B-BS, Brown MJ, Lee D, Holt DA

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127097 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 31.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14757 (Residues: 1-273; Coverage: 57%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:
pentapeptide fragment Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 433 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand 199 1 x 199
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 44.901Å b: 66.056Å c: 58.135Å
α: 90° β: 94.6° γ: 90°
R-values:
R R work R free
0.227 0.227 0.26
Expression systems:
  • Spodoptera frugiperda
  • Not provided

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