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STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00170
Domain description: bZIP transcription factor
Occurring in:
  1. Protein c-Fos
  2. Transcription factor Jun
The deposited structure of PDB entry 1a02 contains 1 copy of Pfam domain PF00170 (bZIP transcription factor) in Protein c-Fos. Showing 1 copy in chain D [auth F].
The deposited structure of PDB entry 1a02 contains 1 copy of Pfam domain PF00170 (bZIP transcription factor) in Transcription factor Jun. Showing 1 copy in chain E [auth J].

PF16179
Domain description: Rel homology dimerisation domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
The deposited structure of PDB entry 1a02 contains 1 copy of Pfam domain PF16179 (Rel homology dimerisation domain) in Nuclear factor of activated T-cells, cytoplasmic 2. Showing 1 copy in chain C [auth N].

PF00554
Domain description: Rel homology DNA-binding domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
The deposited structure of PDB entry 1a02 contains 1 copy of Pfam domain PF00554 (Rel homology DNA-binding domain) in Nuclear factor of activated T-cells, cytoplasmic 2. Showing 1 copy in chain C [auth N].

InterPro InterPro annotations
IPR008366
Domain description: Nuclear factor of activated T cells (NFAT)
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR004827
Domain description: Basic-leucine zipper domain
Occurring in:
  1. Protein c-Fos
  2. Transcription factor Jun
IPR000837
Domain description: AP-1 transcription factor
Occurring in:
  1. Protein c-Fos
IPR002112
Domain description: Transcription factor Jun
Occurring in:
  1. Transcription factor Jun
IPR011539
Domain description: Rel homology domain, DNA-binding domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR046347
Domain description: Basic-leucine zipper domain superfamily
Occurring in:
  1. Protein c-Fos
  2. Transcription factor Jun
IPR032397
Domain description: Rel homology dimerisation domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR002909
Domain description: IPT domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR008967
Domain description: p53-like transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR037059
Domain description: Rel homology domain (RHD), DNA-binding domain superfamily
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2

Structure domains

CATH CATH domains
1.20.5.170
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Protein c-Fos
  2. Transcription factor Jun
The deposited structure of PDB entry 1a02 contains 1 copy of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Protein c-Fos. Showing 1 copy in chain D [auth F].
The deposited structure of PDB entry 1a02 contains 1 copy of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Transcription factor Jun. Showing 1 copy in chain E [auth J].
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
The deposited structure of PDB entry 1a02 contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Nuclear factor of activated T-cells, cytoplasmic 2. Showing 1 copy in chain C [auth N].
2.60.40.340
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Rel homology domain (RHD), DNA-binding domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
The deposited structure of PDB entry 1a02 contains 1 copy of CATH domain 2.60.40.340 (Immunoglobulin-like) in Nuclear factor of activated T-cells, cytoplasmic 2. Showing 1 copy in chain C [auth N].
SCOP SCOP annotations
57960
Class: Coiled coil proteins
Fold: Parallel coiled-coil
Superfamily: Leucine zipper domain
Occurring in:
  1. Protein c-Fos
  2. Transcription factor Jun
The deposited structure of PDB entry 1a02 contains 1 copy of SCOP domain 57960 (Leucine zipper domain) in Protein c-Fos. Showing 1 copy in chain D [auth F].
The deposited structure of PDB entry 1a02 contains 1 copy of SCOP domain 57960 (Leucine zipper domain) in Transcription factor Jun. Showing 1 copy in chain E [auth J].
81279
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
The deposited structure of PDB entry 1a02 contains 1 copy of SCOP domain 81279 (NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain) in Nuclear factor of activated T-cells, cytoplasmic 2. Showing 1 copy in chain C [auth N].
81315
Class: All beta proteins
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: p53-like transcription factors
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
The deposited structure of PDB entry 1a02 contains 1 copy of SCOP domain 81315 (Rel/Dorsal transcription factors, DNA-binding domain) in Nuclear factor of activated T-cells, cytoplasmic 2. Showing 1 copy in chain C [auth N].

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