› 1a12

X-ray diffraction
1.7Å resolution

REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN

Released:
DOI: 10.2210/pdb1a12/pdb
PDB entry 1a12 coloured by chain, front view.
PDB entry 1a12 coloured by chain, side view.
PDB entry 1a12 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller.
Renault L, Nassar N, Vetter I, Becker J, Klebe C, Roth M, Wittinghofer A
Nature 392 97-101 (1998)
PMID: 9510255

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of chromosome condensation Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 413 amino acids
Theoretical weight: 44.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18754 (Residues: 9-421; Coverage: 98%)
Gene names: CHC1, RCC1
Sequence domains: Regulator of chromosome condensation (RCC1) repeat
Structure domains: Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P1
Unit cell:
a: 48.957Å b: 82.903Å c: 83.105Å
α: 112.88° β: 104.09° γ: 103.42°
R-values:
R R work R free
0.189 0.189 0.219
Expression system: Escherichia coli

Quick links

Citations

48 review citations

Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils et al. (2013)
47 more

67 mentions without citation

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.
Wang et al. (2012)
66 more