› 1a4s

X-ray diffraction
2.1Å resolution

BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER

Released:
DOI: 10.2210/pdb1a4s/pdb
PDB entry 1a4s coloured by chain, front view.
PDB entry 1a4s coloured by chain, side view.
PDB entry 1a4s coloured by chain, top view.
Source organism: Gadus morhua callarias
Primary publication:
Structure of betaine aldehyde dehydrogenase at 2.1 A resolution.
Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jörnvall H, Eklund H
Protein Sci 7 2106-17 (1998)
PMID: 9792097

Function and Biology Details

Reactions catalysed: 
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
4-trimethylammoniobutanal + NAD(+) + H(2)O = 4-trimethylammoniobutanoate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157488 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-trimethylaminobutyraldehyde dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 503 amino acids
Theoretical weight: 54.42 KDa
Source organism: Gadus morhua callarias
UniProt:
  • Canonical: P56533 (Residues: 1-503; Coverage: 100%)
Gene name: aldh9A1
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P1
Unit cell:
a: 84.17Å b: 86.22Å c: 88.33Å
α: 105.2° β: 115.13° γ: 100.02°
R-values:
R R work R free
0.223 0.223 0.253

Quick links

Citations

2 review citations

FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism.
Krupenko SA. (2009)
1 more

6 mentions without citation

Prediction of catalytic residues using Support Vector Machine with selected protein sequence and structural properties.
Petrova et al. (2006)
5 more