› 1ahd

Solution NMR

DETERMINATION OF THE NMR SOLUTION STRUCTURE OF AN ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX

Released:
DOI: 10.2210/pdb1ahd/pdb
PDB entry 1ahd coloured by chain, ensemble of 16 models, front view.
PDB entry 1ahd coloured by chain, ensemble of 16 models, side view.
PDB entry 1ahd coloured by chain, ensemble of 16 models, top view.
Source organism: Drosophila subobscura
Primary publication:
Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex.
Billeter M, Qian YQ, Otting G, Müller M, Gehring W, Wüthrich K
J Mol Biol 234 1084-93 (1993)
PMID: 7903398

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113422 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Homeotic protein antennapedia Chain: P
Molecule details ›
Chain: P
Length: 68 amino acids
Theoretical weight: 8.66 KDa
Source organism: Drosophila subobscura
Expression system: Escherichia coli
UniProt:
  • Canonical: Q24645 (Residues: 313-379; Coverage: 17%)
Gene name: Antp
Sequence domains: Homeodomain
Structure domains: Homeodomain-like
DNA (5'-D(*GP*AP*AP*AP*GP*CP*CP*AP*TP*TP*AP*GP*AP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 14 nucleotides
Theoretical weight: 4.34 KDa
Source organism: Drosophila subobscura
Expression system: Not provided
DNA (5'-D(*CP*TP*CP*TP*AP*AP*TP*GP*GP*CP*TP*TP*TP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 14 nucleotides
Theoretical weight: 4.22 KDa
Source organism: Drosophila subobscura
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

30 review citations

Origins of specificity in protein-DNA recognition.
Rohs et al. (2010)
29 more

11 mentions without citation

The DNA-binding region of RAG 1 is not a homeodomain.
Banerjee-Basu et al. (2002)
10 more