› 1aj1

Solution NMR

NMR STRUCTURE OF THE LANTIBIOTIC ACTAGARDINE

Released:
DOI: 10.2210/pdb1aj1/pdb
PDB entry 1aj1 coloured by chain, ensemble of 15 models, front view.
PDB entry 1aj1 coloured by chain, ensemble of 15 models, side view.
PDB entry 1aj1 coloured by chain, ensemble of 15 models, top view.
Source organism: Actinoplanes liguriensis
Primary publication:
The three-dimensional solution structure of the lantibiotic murein-biosynthesis-inhibitor actagardine determined by NMR.
Zimmermann N, Jung G
Eur J Biochem 246 809-19 (1997)
PMID: 9219543

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157513 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lantibiotic actagardine Chain: A
Molecule details ›
Chain: A
Length: 19 amino acids
Theoretical weight: 1.88 KDa
Source organism: Actinoplanes liguriensis
UniProt:
  • Canonical: P56650 (Residues: 46-64; Coverage: 30%)
Gene name: garA

Ligands and Environments

No bound ligands
2 modified residues:
Ligand DAL 1 x DAL
Ligand DBB 3 x DBB

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, ITERATIVE RELAXATION MATRIX REFINEMENT, RESTRAINED MOLECULAR DYNAMICS

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Citations

9 review citations

Lantibiotics: biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria.
Sahl et al. (1998)
8 more

2 mentions without citation

Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation.
Cudic et al. (2002)
1 more