EC 1.6.2.4: NADPH--hemoprotein reductase
Reaction catalysed:
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein
Systematic name:
NADPH:hemoprotein oxidoreductase
Alternative Name(s):
- Aldehyde reductase (NADPH-dependent)
- CPR
- Cytochrome P-450 reductase
- Cytochrome P450 reductase
- Cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)
- Dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase
- FAD-cytochrome c reductase
- Ferrihemoprotein P-450 reductase
- NADP--cytochrome c reductase
- NADP--cytochrome reductase
- NADPH--cytochrome P-450 oxidoreductase
- NADPH--cytochrome P450 oxidoreductase
- NADPH--cytochrome P450 reductase
- NADPH--cytochrome c oxidoreductase
- NADPH--cytochrome c reductase
- NADPH--cytochrome p-450 reductase
- NADPH--ferricytochrome c oxidoreductase
- NADPH--ferrihemoprotein reductase
- NADPH-dependent cytochrome c reductase
- NADPH:P-450 reductase
- NADPH:P450 reductase
- NADPH:ferrihemoprotein oxidoreductase
- POR
- Reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
- Reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
- TPNH(2) cytochrome c reductase
- TPNH-cytochrome c reductase
GO terms
Biochemical function:
- NADP binding
- flavin adenine dinucleotide binding
- iron-cytochrome-c reductase activity
- enzyme binding
- hydrolase activity
- oxidoreductase activity
- FMN binding
- electron transfer activity
- nitric oxide dioxygenase NAD(P)H activity
- cytochrome-b5 reductase activity, acting on NAD(P)H
- NADPH-hemoprotein reductase activity
Biological process:
- cellular organofluorine metabolic process
- regulation of cholesterol metabolic process
- positive regulation of steroid hormone biosynthetic process
- response to dexamethasone
- cellular response to peptide hormone stimulus
- cellular response to follicle-stimulating hormone stimulus
- cellular response to gonadotropin stimulus
- demethylation
- nitric oxide catabolic process
- positive regulation of smoothened signaling pathway
- positive regulation of cholesterol biosynthetic process
- nitrate catabolic process
- negative regulation of apoptotic process
- positive regulation of chondrocyte differentiation
- electron transport chain
- fatty acid oxidation
- flavonoid metabolic process
- response to hormone
- carnitine metabolic process
- response to xenobiotic stimulus
- response to nutrient
- regulation of growth plate cartilage chondrocyte proliferation
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR039261
Domain description:
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Occurring in:
Occurring in:
IPR023173
Domain description:
NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Occurring in:
Occurring in:
IPR003097
Domain description:
Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Occurring in:
Occurring in:
Structure domains
CATH domains
2.40.30.10
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
Elongation Factor Tu (Ef-tu); domain 3
Homology:
Translation factors
Occurring in:
3.40.50.80
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
Occurring in:
1.20.990.10
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
NADPH-cytochrome p450 Reductase; Chain A, domain 3
Homology:
NADPH-cytochrome p450 Reductase; Chain A, domain 3
Occurring in:
SCOP annotations
52365
Class:
Alpha and beta proteins (a/b)
Fold:
Ferredoxin reductase-like, C-terminal NADP-linked domain
Superfamily:
Ferredoxin reductase-like, C-terminal NADP-linked domain
Occurring in:
50438
Class:
All beta proteins
Fold:
Reductase/isomerase/elongation factor common domain
Superfamily:
Riboflavin synthase domain-like
Occurring in:
52231
Class:
Alpha and beta proteins (a/b)
Fold:
Flavodoxin-like
Superfamily:
Flavoproteins
Occurring in:
