› 1an4

X-ray diffraction
2.9Å resolution

STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF

Released:
DOI: 10.2210/pdb1an4/pdb
PDB entry 1an4 coloured by chain, front view.
PDB entry 1an4 coloured by chain, side view.
PDB entry 1an4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and function of the b/HLH/Z domain of USF.
Ferré-D'Amaré AR, Pognonec P, Roeder RG, Burley SK
EMBO J 13 180-9 (1994)
PMID: 8306960

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113430 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Upstream stimulatory factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 65 amino acids
Theoretical weight: 7.65 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: P22415 (Residues: 197-260; Coverage: 21%)
Gene names: BHLHB11, USF, USF1
Sequence domains: Helix-loop-helix DNA-binding domain
Structure domains: Helix-loop-helix DNA-binding domain
DNA (5'-D(*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*C P*TP*AP*CP*A)-3') Chain: C
Molecule details ›
Chain: C
Length: 21 nucleotides
Theoretical weight: 6.37 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*C P*GP*GP*GP*T)-3') Chain: D
Molecule details ›
Chain: D
Length: 21 nucleotides
Theoretical weight: 6.52 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 136.6Å b: 54.7Å c: 44.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.236 not available
Expression systems:
  • Bacteria
  • Not provided

Quick links

Citations

28 review citations

c-Myc target genes involved in cell growth, apoptosis, and metabolism.
Dang CV. (1999)
27 more

19 mentions without citation

Absence of a simple code: how transcription factors read the genome.
Slattery et al. (2014)
18 more