› 1ant

X-ray diffraction
3Å resolution

BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN

Released:
DOI: 10.2210/pdb1ant/pdb
PDB entry 1ant coloured by chain, front view.
PDB entry 1ant coloured by chain, side view.
PDB entry 1ant coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biological implications of a 3 A structure of dimeric antithrombin.
Carrell RW, Stein PE, Fermi G, Wardell MR
Structure 2 257-70 (1994)
PMID: 8087553

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antithrombin-III Chains: I, L
Molecule details ›
Chains: I, L
Length: 432 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 70.06Å b: 101.52Å c: 90.45Å
α: 90° β: 105.9° γ: 90°
R-values:
R R work R free
0.214 0.214 not available
Expression system: Not provided

Quick links

Citations

37 review citations

Conformational disease.
Carrell et al. (1997)
36 more

3 mentions without citation

Prediction of calcium-binding sites by combining loop-modeling with machine learning.
Liu et al. (2009)
2 more