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NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE

Solution NMR
PDB entry 1aot coloured by chain, front view.
PDB entry 1aot coloured by chain, side view.
PDB entry 1aot coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Fyn and Middle T antigen
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Multimeric state: hetero dimer
Accessible surface area: 7796.68 Å2
Buried surface area: 904.12 Å2
Dissociation area: 452.06 Å2
Dissociation energy (ΔGdiss): 2.65 kcal/mol
Dissociation entropy (TΔSdiss): 8.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136550

Macromolecules

Tyrosine-protein kinase Fyn
Chain: F
Length: 106 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 143-248; Coverage: 20%)
Gene name: FYN
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
Tyrosine-protein kinase Fyn in PDB entry 1aot, assembly 1, front view.
Tyrosine-protein kinase Fyn in PDB entry 1aot, assembly 1, side view.
Tyrosine-protein kinase Fyn in PDB entry 1aot, assembly 1, top view.
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Middle T antigen
Chain: P
Length: 11 amino acids
Theoretical weight: 1.47 KDa
Source organism: Mesocricetus auratus polyomavirus 1
UniProt:
  • Canonical: P03079 (Residues: 321-331; Coverage: 3%)
Middle T antigen in PDB entry 1aot, assembly 1, front view.
Middle T antigen in PDB entry 1aot, assembly 1, side view.
Middle T antigen in PDB entry 1aot, assembly 1, top view.
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