› 1aqd

X-ray diffraction
2.45Å resolution

HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE

Released:
DOI: 10.2210/pdb1aqd/pdb
PDB entry 1aqd coloured by chain, front view.
PDB entry 1aqd coloured by chain, side view.
PDB entry 1aqd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding.
Murthy VL, Stern LJ
Structure 5 1385-96 (1997)
PMID: 9351812

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135319 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 192 amino acids
Theoretical weight: 22.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01903 (Residues: 26-217; Coverage: 84%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1 beta chain Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 198 amino acids
Theoretical weight: 22.96 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01911 (Residues: 30-227; Coverage: 84%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:
HLA class I histocompatibility antigen, A alpha chain Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 15 amino acids
Theoretical weight: 1.86 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04439 (Residues: 127-141; Coverage: 4%)
Gene names: HLA-A, HLAA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2
Unit cell:
a: 134.514Å b: 134.32Å c: 131.232Å
α: 90° β: 104.82° γ: 90°
R-values:
R R work R free
0.216 0.216 0.279
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

13 review citations

Endoplasmic reticulum stress sensing in the unfolded protein response.
Gardner et al. (2013)
12 more

83 mentions without citation

Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.
Painter et al. (2012)
82 more