Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
- not assigned
Cellular component:
Structure analysis Details
Assembly composition:
hetero 300-mer (preferred)
Assembly name:
Capsid protein VP3 and peptide (preferred)
PDBe Complex ID:
PDB-CPX-136708 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Capsid protein VP1
Molecule details ›
Chain: 1
Length: 302 amino acids
Theoretical weight: 33.49 KDa
Source organism: Human poliovirus 1 Mahoney
Expression system: Not provided
UniProt:
Structure domains: Jelly Rolls
Length: 302 amino acids
Theoretical weight: 33.49 KDa
Source organism: Human poliovirus 1 Mahoney
Expression system: Not provided
UniProt:
- Canonical:
P03300 (Residues: 580-881; Coverage: 14%)
Structure domains: Jelly Rolls
Capsid protein VP2
Molecule details ›
Chain: 2
Length: 272 amino acids
Theoretical weight: 30.1 KDa
Source organism: Human poliovirus 1 Mahoney
Expression system: Not provided
UniProt:
Structure domains: Jelly Rolls
Length: 272 amino acids
Theoretical weight: 30.1 KDa
Source organism: Human poliovirus 1 Mahoney
Expression system: Not provided
UniProt:
- Canonical: P03300 (Residues: 70-341; Coverage: 12%)
Structure domains: Jelly Rolls
Capsid protein VP3
Molecule details ›
Chain: 3
Length: 238 amino acids
Theoretical weight: 26.55 KDa
Source organism: Human poliovirus 1 Mahoney
Expression system: Not provided
UniProt:
Structure domains: Jelly Rolls
Length: 238 amino acids
Theoretical weight: 26.55 KDa
Source organism: Human poliovirus 1 Mahoney
Expression system: Not provided
UniProt:
- Canonical: P03300 (Residues: 342-579; Coverage: 11%)
Structure domains: Jelly Rolls
Capsid protein VP4
Molecule details ›
Chain: 4
Length: 68 amino acids
Theoretical weight: 7.39 KDa
Source organism: Human poliovirus 1 Mahoney
Expression system: Not provided
UniProt:
Structure domains: Picornavirus coat protein VP4
Length: 68 amino acids
Theoretical weight: 7.39 KDa
Source organism: Human poliovirus 1 Mahoney
Expression system: Not provided
UniProt:
- Canonical: P03300 (Residues: 2-69; Coverage: 3%)
Structure domains: Picornavirus coat protein VP4
