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Human activated protein C

X-ray diffraction
2.8Å resolution
PDB entry 1aut coloured by chain, front view.
PDB entry 1aut coloured by chain, side view.
PDB entry 1aut coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Active Protein C complex
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Multimeric state: hetero dimer
Accessible surface area: 17402.91 Å2
Buried surface area: 1707.37 Å2
Dissociation area: 853.69 Å2
Dissociation energy (ΔGdiss): -2.13 kcal/mol
Dissociation entropy (TΔSdiss): 11.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137386
Complex Portal ID: CPX-6224

Macromolecules

Vitamin K-dependent protein C heavy chain
Chain: C
Length: 250 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04070 (Residues: 212-461; Coverage: 56%)
Gene name: PROC
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Vitamin K-dependent protein C heavy chain in PDB entry 1aut, assembly 1, front view.
Vitamin K-dependent protein C heavy chain in PDB entry 1aut, assembly 1, side view.
Vitamin K-dependent protein C heavy chain in PDB entry 1aut, assembly 1, top view.
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Vitamin K-dependent protein C light chain
Chain: L
Length: 114 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04070 (Residues: 84-197; Coverage: 26%)
Gene name: PROC
Pfam: Coagulation Factor Xa inhibitory site
InterPro:
CATH: Laminin
SCOP: EGF-type module
Vitamin K-dependent protein C light chain in PDB entry 1aut, assembly 1, front view.
Vitamin K-dependent protein C light chain in PDB entry 1aut, assembly 1, side view.
Vitamin K-dependent protein C light chain in PDB entry 1aut, assembly 1, top view.
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