EC 3.4.21.69: Protein C (activated)
Reaction catalysed:
Degradation of blood coagulation factors Va and VIIIa.
Systematic name:
-
Alternative Name(s):
- APC
- Activated blood coagulation factor XIV
- Activated protein C
- Autoprothrombin II-A
- Autoprothrombin IIA
- Blood-coagulation factor XIVa
- GSAPC
- Protein Ca
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Protein families (Pfam)![The deposited structure of PDB entry 1aut contains 1 copy of Pfam domain PF14670 (Coagulation Factor Xa inhibitory site) in Vitamin K-dependent protein C light chain. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1aut_2_L_Pfam_PF14670_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1aut</span> contains 1 copy of Pfam domain <span class='highlight'>PF14670 (Coagulation Factor Xa inhibitory site)</span> in <span class='highlight'>Vitamin K-dependent protein C light chain</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>.")
![The deposited structure of PDB entry 1aut contains 1 copy of Pfam domain PF00089 (Trypsin) in Vitamin K-dependent protein C heavy chain. Showing 1 copy in chain A [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/1aut_1_C_Pfam_PF00089_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1aut</span> contains 1 copy of Pfam domain <span class='highlight'>PF00089 (Trypsin)</span> in <span class='highlight'>Vitamin K-dependent protein C heavy chain</span>. Showing 1 copy in chain <span class='highlight'>A [auth C]</span>.")
InterPro annotations
CATH domains![The deposited structure of PDB entry 1aut contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Vitamin K-dependent protein C heavy chain. Showing 2 copies in chain A [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/1aut_1_C_CATH_2.40.10.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1aut</span> contains 2 copies of CATH domain <span class='highlight'>2.40.10.10 (Thrombin, subunit H)</span> in <span class='highlight'>Vitamin K-dependent protein C heavy chain</span>. Showing 2 copies in chain <span class='highlight'>A [auth C]</span>.")
![The deposited structure of PDB entry 1aut contains 2 copies of CATH domain 2.10.25.10 (Laminin) in Vitamin K-dependent protein C light chain. Showing 2 copies in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1aut_2_L_CATH_2.10.25.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1aut</span> contains 2 copies of CATH domain <span class='highlight'>2.10.25.10 (Laminin)</span> in <span class='highlight'>Vitamin K-dependent protein C light chain</span>. Showing 2 copies in chain <span class='highlight'>B [auth L]</span>.")
SCOP annotations![The deposited structure of PDB entry 1aut contains 2 copies of SCOP domain 57197 (EGF-type module) in Vitamin K-dependent protein C light chain. Showing 2 copies in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1aut_2_L_SCOP_57197_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1aut</span> contains 2 copies of SCOP domain <span class='highlight'>57197 (EGF-type module)</span> in <span class='highlight'>Vitamin K-dependent protein C light chain</span>. Showing 2 copies in chain <span class='highlight'>B [auth L]</span>.")
![The deposited structure of PDB entry 1aut contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Vitamin K-dependent protein C heavy chain. Showing 1 copy in chain A [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/1aut_1_C_SCOP_50514_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1aut</span> contains 1 copy of SCOP domain <span class='highlight'>50514 (Eukaryotic proteases)</span> in <span class='highlight'>Vitamin K-dependent protein C heavy chain</span>. Showing 1 copy in chain <span class='highlight'>A [auth C]</span>.")